Associate Professor of Biological Sciences
Molecular and Cellular Biology Graduate Program
Cancer Biology and Developmental Therapeutics Research Program, Norris Cotton Cancer Center
I am interested in how complex tissue and organ structures arise from simple tissue primordia. Tissue morphogenesis is not only controlled biochemically but also an intrinsically mechanical process. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, I seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.
- B.S. Peking University
- Ph. D. University of Pennsylvania
Hanqing Guo, Shicheng Huang, Bing He. (2022) Evidence for a role of the lateral ectoderm in Drosophila mesoderm invagination. Front. Cell Dev. Biol.. doi: 10.3389/fcell.2022.867438.
Wei Chen, Bing He. (2022) Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction. J Cell Biol. 221(6). doi: 10.1083/jcb.202103069.
Hanqing Guo, Michael Swan, Bing He. (2022) Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination. Elife 11:e69082. doi: 10.7554/eLife.69082.
Melisa Fuentes, Bing He. (2022) The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination. Development. 149(6):dev200468. doi: 10.1242/dev.200468.
Samuel Reed*, Wei Chen*, Victoria Bergstein, Bing He. (2022) Toll-Dorsal signaling regulates the spatiotemporal dynamics of yolk granule tubulation during Drosophila cleavage. Dev Biol. 481:64-74. doi: 10.1016/j.ydbio.2021.09.009. * These authors contributed equally.
Bing He*, Adam Martin, Eric Wieschaus. (2016) Flow-dependent myosin recruitment during Drosophila cellularization requires zygotic dunk activity. Development 143(13):2417-30. * Corresponding author.
Bing He, Konstantin Doubrovinski, Oleg Polyakov, Eric Wieschaus (2014) Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. Nature 508(7496):392-6.
Oleg Polyakov, Bing He, Michael Swan, Joshua Shaevitz, Matthias Kaschube, Eric Wieschaus (2014). Passive mechanical forces control cell shape change during Drosophila ventral furrow formation. Biophysical Journal 107(4):998-1010.
Bing He, Amy Caudy, Lance Parsons, Adam Rosebrock, Attilio Pane, Sandeep
Raj, Eric Wieschaus (2012) Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster. Genome Research 22(12):2507-19.
Michael Gelbart, Bing He, Adam Martin, Stephan Thiberge, Eric Wieschaus, Matthias Kaschube (2012) Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis. PNAS 109 (47):19298-303.
Jianglan Liu, Yuting Zhao, Yujie Sun, Bing He, Changsong Yang, Tatyana Svitkina, Yale Goldman, Wei Guo (2012) Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration. Curr Biol 22 (16):1510-5.
Bing He and Wei Guo (2009) The exocyst complex in polarized exocytosis. Review. Current Opinion in Cell Biology 21(4):537-42.
Xiaoyu Zhang, Kelly Orlando, Bing He, Fengong Xi, Jian Zhang, Allison Zajac, Wei Guo (2008) Membrane association and functional regulation of Sec3 by phospholipids and Cdc42. Journal of Cell Biology 180(1):145-58.
Bing He, Fengong Xi, Xiaoyu Zhang, Jian Zhang, Wei Guo (2007) Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. The EMBO Journal 26(24):5167.
Bing He, Fengong Xi, Jian Zhang, Daniel TerBush, Xiaoyu Zhang, Wei Guo (2007) Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth. Journal of Cell Biology 176(6):771-7.