Carey D. Nadell

Selected Publications

• Robitaille, S., Simmons, E.L., Verster, A.J., McClure, E.A., Royce, D.B., Swartz, K., Schultz, D., Nadell, C.D., Ross, B.D. (2023). Community composition and the environment modulate the population dynamics of Type IV secretion in human gut bacteria. (2023). Nature Ecology and Evolution (in press)

  Smith, W.P.J., Wucher, B.R., Nadell, C,D., Foster, K.R. (2023). Bacterial defences: mechanisms, evolution, and antimicrobial resistance. Nature Reviews Microbiology 21: 519-534

  Wucher, B.R., Winans, J.B., Elsayed, M., Kadouri, D.E., Nadell, C.D†. (2023). Breakdown of clonal cooperative architecture in multispecies biofilms and the spatial ecology of predation. PNAS 120(6): e2212650120.

  Winans, J.B., Wucher, B.R., Nadell, C.D†. (2022). Multispecies biofilm architecture determines bacterial exposure to phages. PLoS Biology: e3001913

  Huber, M., Lippegaus, A., Melamed, S., Siemers, M., Wucher, B.R.*, Nadell, C.D., Storz, G., Papenfort, K. (2022). An RNA sponge controlling quorum sensing dynamics and biofilm formation in Vibrio cholerae. Nature Communications13: 7585

  Teschler, J.K., Jiménez-Siebert, E., Jeckel, H., Singh, P.K., Park, J.H., Pukatzki, S., Nadell, C.D., Drescher. K., Yildiz, F.H. (2022) VxrB Influences Antagonism within Biofilms by Controlling Competition through Extracellular Matrix Production and Type 6 Secretion. mBio. Jul 26:e0188522. doi: 10.1128/mbio.01885-22. Online ahead of print. PMID: 35880882

  Tai, J.B., Mukherjee, S., Nero, T., Olson, R., Tithof, J., Nadell, C.D., Yan, J. (2022) Social evolution of shared biofilm matrix components. Proc Natl Acad Sci U S A. Jul 5;119(27):e2123469119. doi: 10.1073/pnas.2123469119. Epub 2022 Jun 30. PMID: 35771939

  Teschler, J.K., Nadell, C.D., Drescher, K., Yildiz, F.H. (2022) Mechanisms Underlying Vibrio cholerae Biofilm Formation and Dispersion. Annu Rev Microbiol. 2022 Jun 7. doi: 10.1146/annurev-micro-111021-053553. Online ahead of print. PMID: 35671532

  Kerkaert, J.D., Le Mauff, F., Wucher, B.R., Beattie, S.R., Vesely, E.M., Sheppard, D.C., Nadell, C.D., Cramer, R.A. (2022) An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment. mBio. Apr 26;13(2):e0293321. doi: 10.1128/mbio.02933-21. Epub 2022 Mar 7. PMID: 35254131

  Kasetty, S., Katharios-Lanwermeyer, S., O'Toole, G.A., Nadell, C.D. (2021) Differential Surface Competition and Biofilm Invasion Strategies of Pseudomonas aeruginosa PA14 and PAO1. J Bacteriol. 2021 Oct 25;203(22):e0026521. doi: 10.1128/JB.00265-21. Epub 2021 Sep 13. PMID: 34516283

  Koeppen, K., Nymon, A., Barnaby, R., Bashor, L., Li, Z., Hampton, T.H., Liefeld, A.E., Kolling, F.W., LaCroix, I.S., Gerber, S.A., Hogan, D.A., Kasetty, S., Nadell, C.D., Stanton, B.A. (2021) Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2105370118. doi: 10.1073/pnas.2105370118. PMID: 34260396

  Bond. M.C., Vidakovic, L., Singh, P.K., Drescher, K., Nadell, C.D. (2021) Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. Elife. Jul 9;10:e65355. doi: 10.7554/eLife.65355. PMID: 34240700

  Kasetty, S., Mould, D.L., Hogan, D.A., Nadell, C.D. (2021) Both Pseudomonas aeruginosa and Candida albicans Accumulate Greater Biomass in Dual-Species Biofilms under Flow. mSphere. Jun 30;6(3):e0041621. doi: 10.1128/mSphere.00416-21. Epub 2021 Jun 23. PMID: 34160236

  Wucher BR, Elsayed M, Adelman JS, Kadouri DE, Nadell CD† (2021). Bacterial predation transforms the landscape and community assembly of biofilms. Current Biology 31: 1-9

• Bond MC, Vidakovic L, Singh PK, Drescher K, Nadell CD†. (2021). Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. eLife 10:e65355

• Kasetty D, Mould DL, Hogan DA, Nadell CD†. (2021). Both Pseudomonas aeruginosa and Candida albicans accumulate greater biomass in dual-species biofilm under flow. mSphere 6(3): e00416-21

• Kowalski CH, Morelli KA, Stajich JE, Nadell CD, Cramer RA (2021). A heterogeneously expressed gene family modulates the biofilm architecture and hypoxic growth of Aspergillus fumigatus. mBio 12(1): e03579-20

• Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefield AE, Kolling FW, LaCroix IS, Gerber S, Hogan DA, Kasetty K, Nadell CD, Stanton BA. (2021). Let-7b-5c in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic susceptibility of P. aeruginosa. Proceedings of the National Academy of Sciences USA 118(28): e2105370118

• Kowalski CH, Morelli KA, Schultz D, Nadell CD, Cramer RA. (2020) Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance. Proceedings of the National Academy of Sciences USA.  Sep 8;117(36):22473-22483

• Simmons EL, Bond MC, Koskella B, Drescher K, Bucci V, Nadell CD. (2020) Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria. mSystems. Jun 23;5(3):e00877

• Díaz-Pascual F, Hartmann R, Lempp M, Vidakovic L, Song B, Jeckel H, Thormann KM, Yildiz FH, Dunkel J, Link H, Nadell CD, Drescher K. (2019) Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function. Nature Microbiology. Dec;4(12):2136-2145

• Kitts G, Giglio KM, Zamorano-Sánchez D, Park JH, Townsley L, Cooley RB, Wucher BR, Klose KE, Nadell CD, Yildiz FH, Sondermann H. (2019) A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae. mBio. Dec 3;10(6):e02822-19

• Wucher BW, Bartlett TM, Persat A, Nadell CD (2019). Vibrio cholerae filamentation promotes chitin surface attachment at the expense of competition in biofilms. Proceedings of the National Academy of Sciences USA 116(28): 14216-14221

• Rossy T, Nadell CD, Persat A. (2018). Cellular advection-diffusion drives emergence of bacterial surface colonization patterns and heterogeneity. Nature Communications 10(1): 2471

• Martinez-Garcia R, Nadell CD, Hartmann R, Drescher K, Bonachela J† (2018). Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms. PLoS Computational Biology 14(4): e1006094

• Vidakovic L, Singh PK, Hartmann R, Nadell CD, Drescher K. (2018). Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Nature Microbiology 3: 26-31

• Simmons M, Drescher K, Nadell CD, Bucci V.  (2017). Phage mobility is a core determinant of phage–bacteria coexistence in biofilms. ISME Journal 12: 531-543

• Singh PK, Hartmann R, Bartolomej S, Nadell CD, Drescher K. (2017). Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal. Current Biology 27: 1-8

• Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL (2017). Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Nature Communications 8: 327

• Nadell CD, Ricaurte D*, Yan J, Drescher K, Bassler B (2017). Flow environment and matrix structure interact to shape spatial competition in P. aeruginosa biofilms. eLife 6: e21855

• Nadell CD, Hartmann R, Drescher K. (2016) An emerging grip on the growth of grounded bacteria. ACS Nano 10:9109-9110   (commentary)

• Nadell CD, Drescher K, Foster KR. (2016) Spatial structure, cooperation, and competition in biofilms. Nature Reviews Microbiology 14: 589-600  

• Drescher K, Dunkel J, Nadell CD, van Teeffelen S, Grnja I, Wingreen NS, Stone HA, Bassler BL. (2016) Architectural transitions in Vibrio cholerae biofilm development at single-cell resolution. Proceedings of the National Academy of Sciences USA 113(4): E2066-2072