Carey Davis Nadell

Assistant Professor
Academic Appointments

Assistant Professor of Biological Sciences
Graduate Program in Ecology, Evolution, Environment and Society
Molecular and Cellular Biology Graduate Program

Bacteria often live in groups, called biofilms, where they cooperate and compete with each other using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they impact the world around them. We use tools from ecology, evolution, microscopy, and molecular biology to understand the cell-scale mechanisms and biofilm-scale consequences of bacterial social interaction.

Class of 1978 Life Sciences Center, room 326
HB 6044
Department(s): 
Biological Sciences
Education: 
B.A. University of Oxford
M.A. Princeton University
Ph. D. Princeton University

Selected Publications

Wucher BR, Elsayed M, Adelman JS, Kadouri DE, Nadell CD† (2021). Bacterial predation transforms the landscape and community assembly of biofilms. Current Biology 31: 1-9

Bond MC, Vidakovic L, Singh PK, Drescher K, Nadell CD†. (2021). Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. eLife 10:e65355

Kasetty D, Mould DL, Hogan DA, Nadell CD†. (2021). Both Pseudomonas aeruginosa and Candida albicans accumulate greater biomass in dual-species biofilm under flow. mSphere 6(3): e00416-21

Kowalski CH, Morelli KA, Stajich JE, Nadell CD, Cramer RA (2021). A heterogeneously expressed gene family modulates the biofilm architecture and hypoxic growth of Aspergillus fumigatus. mBio 12(1): e03579-20

Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefield AE, Kolling FW, LaCroix IS, Gerber S, Hogan DA, Kasetty K, Nadell CD, Stanton BA. (2021). Let-7b-5c in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic susceptibility of P. aeruginosa. Proceedings of the National Academy of Sciences USA 118(28): e2105370118

Kowalski CH, Morelli KA, Schultz D, Nadell CD, Cramer RA. (2020) Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance. Proceedings of the National Academy of Sciences USA.  Sep 8;117(36):22473-22483

Simmons EL, Bond MC, Koskella B, Drescher K, Bucci V, Nadell CD. (2020) Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria. mSystems. Jun 23;5(3):e00877

Díaz-Pascual F, Hartmann R, Lempp M, Vidakovic L, Song B, Jeckel H, Thormann KM, Yildiz FH, Dunkel J, Link H, Nadell CD, Drescher K. (2019) Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function. Nature Microbiology. Dec;4(12):2136-2145

Kitts G, Giglio KM, Zamorano-Sánchez D, Park JH, Townsley L, Cooley RB, Wucher BR, Klose KE, Nadell CD, Yildiz FH, Sondermann H. (2019) A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae. mBio. Dec 3;10(6):e02822-19

Wucher BW, Bartlett TM, Persat A, Nadell CD (2019). Vibrio cholerae filamentation promotes chitin surface attachment at the expense of competition in biofilmsProceedings of the National Academy of Sciences USA 116(28): 14216-14221

Rossy T, Nadell CD, Persat A. (2018). Cellular advection-diffusion drives emergence of bacterial surface colonization patterns and heterogeneity. Nature Communications 10(1): 2471

Martinez-Garcia R, Nadell CD, Hartmann R, Drescher K, Bonachela J† (2018). Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms. PLoS Computational Biology 14(4): e1006094

Vidakovic L, Singh PK, Hartmann R, Nadell CD, Drescher K. (2018). Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Nature Microbiology 3: 26-31

Simmons M, Drescher K, Nadell CD, Bucci V.  (2017). Phage mobility is a core determinant of phage–bacteria coexistence in biofilms. ISME Journal 12: 531-543

Singh PK, Hartmann R, Bartolomej S, Nadell CD, Drescher K. (2017). Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal. Current Biology 27: 1-8

Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL (2017). Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Nature Communications 8: 327

Nadell CD, Ricaurte D*, Yan J, Drescher K, Bassler B (2017). Flow environment and matrix structure interact to shape spatial competition in P. aeruginosa biofilms. eLife 6: e21855

Nadell CD, Hartmann R, Drescher K. (2016) An emerging grip on the growth of grounded bacteria. ACS Nano 10:9109-9110   (commentary)

Nadell CD, Drescher K, Foster KR. (2016) Spatial structure, cooperation, and competition in biofilms. Nature Reviews Microbiology 14: 589-600  

Drescher K, Dunkel J, Nadell CD, van Teeffelen S, Grnja I, Wingreen NS, Stone HA, Bassler BL. (2016) Architectural transitions in Vibrio cholerae biofilm development at single-cell resolution. Proceedings of the National Academy of Sciences USA 113(4): E2066-2072

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