Christopher Sandford

Assistant Professor of Chemistry
Academic Appointments

Assistant Professor of Chemistry

Research in the Sandford group focuses on the development of new synthetic methodologies utilizing homogeneous catalysts. The group exploits new tools in physical organic chemistry to study reaction mechanisms involved in catalysis, which allows them to design new catalysts, optimize their structures, and apply their functions to key challenges in organic chemistry. The study of optimal catalysts in this manner also facilitates the development of new sustainable strategies to forge important chemical bonds.

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MChem Merton College, University of Oxford, 2013
PhD University of Bristol, 2017

Selected Publications

Tang, T.; Sandford, C.; Minteer, S. D.; Sigman, M. S. Analyzing Mechanisms in Co(I) Redox Catalysis Using a Pattern Recognition Platform. Chem. Sci. 2021, 12, 4771–4778.

Tsai, C.-C.; Sandford, C.; Wu, T.; Chen, B.; Sigman, M. S.; Toste, F. D. Enantioselective Intramolecular Allylic Substitution via Synergistic Palladium/Chiral Phosphoric Acid Catalysis: Insight into Stereoinduction through Statistical Modeling. Angew. Chem. Int. Ed. 2020, 59, 14647–14655.

Barman, K.; Edwards, M. A.; Hickey, D. P.; Sandford, C.; Qiu, Y.; Gao, R.; Minteer, S. D.; White, H. S. Electrochemical Reduction of [Ni(Mebpy)3]2+: Elucidation of the Redox Mechanism by Cyclic Voltammetry and Steady-State Voltammetry in Low Ionic Strength Solutions. ChemElectroChem 2020, 7, 1473–1479.

Sandford, C.; Fries, L. R.; Ball, T. E.; Minteer, S. D.; Sigman, M. S. Mechanistic Studies into the Oxidative Addition of Co(I) Complexes: Combining Electroanalytical Techniques with Parameterization. J. Am. Chem. Soc. 2019, 141, 18877–18889.

Sandford, C.; Edwards, M. A.; Klunder, K. J.; Hickey, D. P.; Li, M.; Barman, K.; Sigman, M. S.; White, H. S.; Minteer, S. D. A Synthetic Chemist’s Guide to Electroanalytical Tools for Studying Reaction Mechanisms. Chem. Sci. 2019, 10, 6404–6422. 

Hickey, D. P.; Sandford, C.; Rhodes, Z.; Gensch, T.; Fries, L. R.; Sigman, M. S.; Minteer, S. D. Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates. J. Am. Chem. Soc. 2019, 141, 1382–1392.

García-Ruiz, C.; Chen, J. L.-Y.; Sandford, C.; Feeney, K.; Lorenzo, P.; Berionni, G.; Mayr, H.; Aggarwal, V. K. Stereospecific Allylic Functionalization: The Reactions of Allylboronate Complexes with Electrophiles. J. Am. Chem. Soc. 2017, 139, 15324–15327.

Armstrong, R. J.; Sandford, C.; García-Ruiz, C.; Aggarwal, V. K. Conjunctive Functionalization of Vinyl Boronate Complexes with Electrophiles: A Diastereoselective Three-Component Coupling. Chem. Commun. 2017, 53, 4922–4925.

Silvi, M.; Sandford, C.; Aggarwal, V. K. Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes. J. Am. Chem. Soc. 2017, 139, 5736–5739.

Sandford, C.; Aggarwal, V. K. Stereospecific Functionalizations and Transformations of Secondary and Tertiary Boronic Esters. Chem. Commun. 2017, 53, 5481–5494.

Wang, Y.; Noble, A.; Sandford, C.; Aggarwal, V. K. Enantiospecific Trifluoromethyl-Radical-Induced Three Component Coupling of Boronic Esters with Furans. Angew. Chem. Int. Ed. 2017, 56, 1810–1814.

Farley, A. J. M.; Sandford, C.; Dixon, D. J. Bifunctional Iminophosphorane Catalyzed Enantioselective Sulfa Michael Addition to Unactivated α Substituted Acrylate Esters. J. Am. Chem. Soc. 2015, 137, 15992–15995.

Sandford, C.; Rasappan, R.; Aggarwal, V. K. Synthesis of Enantioenriched Alkylfluorides by the Fluorination of Boronate Complexes. J. Am. Chem. Soc. 2015, 137, 10100–10103.

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