Dean E. Wilcox

Academic Appointments
  • Professor of Chemistry

  • Chair of the Department of Chemistry

Dean Wilcox pursued his graduate research with Edward Solomon at MIT (1979-81) and Stanford (1982-84), where he studied the binuclear copper site in the oxygen transport protein hemocyanin (1, 2), the ortho-hydroxylating enzyme tyrosinase (3) and relevant small molecule model compounds (4).

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Burke, Room 113
HB 6128




  • B.S. University of California at Riverside
  • M.S. University of California at Riverside
  • Ph.D. Massachusetts Institute of Technology

Selected Publications

  • George P. Lisi, Russell P. Hughes, Dean E. Wilcox, “Coordination Contributions to Protein Stability in Metal-Substituted Carbonic Anhydrase”, Journal of Biological Inorganic Chemistry, 2016 21, 659-667.

  • Marcelo M. Pedroso, Fernanda Ely, Natasa Mitic, Margaret C. Carpenter, Lawrence R. Gahan, Dean E. Wilcox, James L. Larrabee, David L. Ollis, Gerhard Schenk, “Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH)”, Journal of Biological Inorganic Chemistry 2014 19, 1263-1275.

  • George P. Lisi, Chien Y. M. Png, Dean E. Wilcox, “Thermodynamic Contributions to the Stability of the Insulin Hexamer”, Biochemistry 2014 53, 3576-3584.

  • Margaret C. Carpenter and Dean E. Wilcox, “Thermodynamics of Formation of the Insulin Hexamer: Metal-Stabilized Proton-Coupled Assembly of Quaternary Structure”, Biochemistry 2014 53, 1296-1301.

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Works In Progress

  • M. M. Pedroso, F. Ely, M. C. Carpenter, N. Mitic, L. R. Gahan, D. L. Ollis, D. E. Wilcox, G. Schenk, “Formation of the Catalytic Binuclear Active Site of Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes”, in preparation.

  • C. F. Quinn, D. E. Wilcox, “Thermodynamics of Metal Ions Binding to Metallothionein”, in preparation.

  • M. L. Croteau, D. E. Wilcox, “Thermodynamics of Cu(II) and Cu(I) Binding to Azurin: A Calorimetric Method to Quantify Metalloprotein Reduction Thermodynamics”, in preparation.

  • M. J. Stevenson, J. V. Schuster, D. E. Wilcox, “Thermodynamics of Metal Ions Binding to the Copper Metallochaperone HAH1”, in preparation.

  • H. M. Wahba, M. J. Stevenson, A. Mansour, J. Sygusch, D. E. Wilcox, J. G. Omichinski, “Structural and Biochemical Characterization of Organotin and Organolead Compounds with the Organomercurial Lyase MerB Provide Important Insight into Its Unique Mechanism of Carbon-metal Bond Cleavage”, in preparation.

  • M. J. Stevenson, H. M. Wahba, J. G. Omichinski, D. E. Wilcox, “Thermodynamics of Hg(II) and Other Metal Ions Binding to MerB and Cleavage of the Methyl-mercury Bond”, in preparation.