Erik Griffin

Academic Appointments

Associate Professor of Biology
Associate Professor in the Molecular and Cellular Biology Graduate Program

348 Life Sciences Center
HB 6044
Biological Sciences
B.A., Swarthmore College
Ph.D., California Institute of Technology
Postdoctoral fellow, Johns Hopkins University School of Medicine

Selected Publications

Fan X, De Henau S, Feinstein J, Miller SI, Han B, Frokjaer-Jensen C, Griffin EE (2019) SapTrap Assembly of Caenorhabditis elegans MosSCI transgene vectors. G3. 10(2): 635 - 644.

Wu Y, Han B, Smith J, Singh A, Griffin EE (2019) Single molecule dynamics of the P granule scaffold MEG-3 in the C. elegans zygote. Molecular Biology of the Cell, 30:333-345. 

Gauvin TJ, Han B, Sun MJ, Griffin EE (2018) PIE-1 translation in the germline lineage contributes to PIE-1 asymmetry in the early C. elegans embryo. G3, 8:3791-3801.

Wu Y, Han B, Li Y, Munro E, Odde DJ, Griffin EE (2018) Rapid diffusion-state switching underlies stable cytoplasmic gradients in the Caenorhabditis elegans zygote. PNAS, 115:E8440-E8449.

Han B, Antokowiak KR, Fan X, Rutigliano M, Ryder SP, Griffin EE (2018) Polo-like Kinase couples cytoplasmic protein gradeints in the C. elegans zygote. Current Biology. 28: 60-69.

Wu Y, Griffin EE (2016) Regulation of Cell Polarity by PAR-1/MARK Kinase. Current Topics in Developmental Biology, 123:365-397.

Wu Y, Zhang H, Griffin EE (2015) Coupling between cytoplasmic concentration gradients through local control of protein mobility in the Caenorhabditis elegans zygote. Molecular Biology of the Cell, 26:2963-2970. 

Griffin EE (2015) Cytoplasmic localization and asymmetric division in the early embryo of Caenorhabditis elegans.Wiley Interdisciplinary Reviews: Developmental Biology, 4: 267-282.

Griffin EE, Odde DJ, Seydoux G (2011) Regulation of the MEX-5 gradient by a spatially separated kinase/phosphatase cycle. Cell , Vol 146: 955-968.

Motegi F, Zonies S, Hao Y, Cuenca AA, Griffin EE, Seydoux G (2011)  Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nature Cell Biology, Published online October 9, 2011.

Griffin EE, Chan DC (2006) Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.  Journal of Biological Chemistry, 281: 16599-16606.

Griffin EE, Detmer SA, Chan DC (2006) Molecular mechanism of mitochondrial fusion.  Biochimica et Biophysica Acta - Molecular Cell Reviews, 1763:482-489.

Griffin EE, Graumann J, Chan DC (2005) The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.  Journal of Cell Biology, 170: 237-248.

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