Gordon Wayne Gribble
Professor of Chemistry Emeritus
The Dartmouth Professor of Chemistry Emeritus
Research Professor of Chemistry
Professor Gribble's research program covers several areas of organic chemistry, most of which involve synthesis, including novel indole chemistry, triterpenoid synthesis, DNA intercalation, and new synthetic methodology. Of prime interest is the synthesis of bis-acridines that act as DNA double intercalators, one of which is active against human glioblastoma cells. In the area of new synthetic methodology, Dr. Gribble and his students have discovered new chemistry of nitroindoles. A third area of research is the synthesis and biological activity of triterpenoids in the chemoprevention of cancer and other diseases related to inflammation. One of these synthetic triterpenoids, "bardoxolone methyl" has entered Phase 3 clinical trials for the treatment of chronic kidney disease in diabetes patients.
- A.A. San Francisco City College
- B.S. University of California at Berkeley
- Ph.D. University of Oregon
"Total Synthesis of Atorvastatin via a Late-Stage, Regioselective 1,3-Dipolar Münchnone Cycloaddition"; Lopchuk, J.M; Gribble, G.W. Tetrahedron Lett. 2015, 56, 3208-3211 (Invited for the Henry Wasserman Special Issue).
"Synthesis of Heteraryl-Substituted Pyrroles via the 1,3-Dipolar Cycloaddition of Unsymmetrical Münchnones and Nitrovinyl Heterocycles"; Lopchuk, J.M.; Song, M.; Butler, B.; Gribble, G.W. Synthesis, 2015, 47, 2776-2780 (Invited for a Special Issue on Cycloaddition Reactions and Methods).
"A Recent Survey of Naturally Occurring Organohalogen Compounds"; Gribble, G.W. Environ. Chem. 2015, 12, 396-405 (Special Issue on "Natural Halogenation).
"Novel Synthesis of 1-Bromo-8-methylnaphthalene and 1-Bromo-45-methylnaphthalene"; Onyango, E.O.; Kelley, A.R.; Qian, D.C.; Gribble, G.W. J. Org. Chem. 2015, 80, 5970-5972.
Works In Progress
"Indole Ring Synthesis: From Natural Products to Drug Discovery"
"Captain Aaron Gove Wilkins '1942 – Iwo Jima Marine Corps Hero"