Ivan Aprahamian

Academic Appointments

Professor of Chemistry

The Aprahamian group uses modular and tunable hydrazone-based building blocks in the development of molecular switches, fluorophores, sensors and adaptive materials. To this end we utilize synthetic, physical organic, and supramolecular chemistry in conjunction with advanced spectroscopic methods.

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Our interest in controlling molecular motion and converting it into mechanical work has driven us to the development of new hydrazone-based molecular switches that can be activated either chemically or photochemically. These novel systems are expected to form the basis of various molecular machines and motors that can be used in applications ranging from drug delivery to energy storage.

The group is also developing new hydrazone-based fluorophores that can be used in sensing, bio-imaging, and energy applications, among others.

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Burke 213
HB 6128
B.Sc. The Hebrew University of Jerusalem
M.Sc. The Hebrew University of Jerusalem
Ph.D. The Hebrew University of Jerusalem

Selected Publications

I. Aprahamian, The Future of Molecular Machines, ACS Cent. Sci. 2020, 6, 347–358

X. Guo, B. Shao, S. Zhou, I. Aprahamian, Z. Chen, Visualizing intracellular particles and precise control of drug release using an emissive hydrazone photochrome Chem. Sci. 2020, 11, 3016–3021

L.-Q. Zheng, S. Yang, J. Lan, L. Gyr, G. Goubert, H. Qian, I. Aprahamian, R. Zenobi, Solution phase and surface photoisomerization of a hydrazone switch with long thermal half-life J. Am. Chem. Soc. 2019, 141, 17637–17645

B. Shao, H. Qian, Q. Li, I. Aprahamian, Structure Property Analysis of the Solution and Solid-State Properties of Bistable Photochromic Hydrazones J. Am. Chem. Soc. 2019, 141, 8364−8371

A. Ryabchun, Q. Li, F. Lancia, I. Aprahamian, N. Katsonis, Shape-Persistent Actuators from Hydrazone Photoswitches J. Am. Chem. Soc. 2019, 141, 1196–1200

M. J. Moran, M. Magrini, D. Walba, I. Aprahamian, Driving a Liquid Crystal Phase Transition using a Photochromic Hydrazone J. Am. Chem. Soc. 2018, 140, 13623–13627

B. Shao, M. Baroncini, H. Qian, L. Bussotti, M. Di Donato, A. Credi, I. Aprahamian, Solution and Solid-State Emission Toggling of a Photochromic Hydrazone J. Am. Chem. Soc. 2018, 140, 12323–12327

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