Jimmy Wu

Selected Publications

• "Synthesis of Functionalized Hexahydrocarbazoles by Beckmann Elimination and Nucleophile-Intercepted Beckmann Fragmentation" Saha, D.; Protich, Z.; Wu, J. Org. Lett. 2023, ASAP.

• "Regiodivergent (3 + 2) Annulation Reactions of Oxyallyl Cations" Protich, Z.; Lowder, L. L.; Hughes, R. P.; Wu, J. Chem. Sci. 2023, 14, 5196−5203.

• "Diversification of Nucleophile-Intercepted Beckmann Fragmentation Products and Related Density Functional Theory Studies" Lowder, L. L.; Zhao, F.; Vaughan M. M.; Houk, K. N.; Liu, F.; Wu, J., J. Org. Chem. 2020, 85, 11396–11408.

• "Nucleophile-intercepted Beckmann Fragmentation Reactions" Touchette, S. J.; Dunkley, E. M.; Lowder, L. L. Wu, J. Chem. Sci. 2019, 10, 7812−7815.

• "Nuphar Alkaloids Induce Very Rapid Apoptosis Through a Novel Caspase-Dependent but BAX/BAK-Independent Pathway" Mallick, D. J.; Korotkov, A.; Li, H.; Wu, J.; Eastman, A. Cell Bio. Toxicol. 2019, 35, 435−443.

• "Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space" Kearney, S. E.; Zahoránszky-Kőhalmi, G.; Brimacombe, K. R.; Henderson, M. J.; Lynch, C.; et al. ACS Cent. Sci. 2018, 4, 1727−1741.

• "Catalytic Vinylogous Cross-Coupling Reactions of Rhenium Vinylcarbenoids" Chen, J.; Wu, J. Chem. Sci. 2018, 9, 2489-2492. (One of Angewandte Chemie's Top 20 Most Downloaded recent papers)

• "Synthesis of 2-Aminoimidazolones and Imidazolones by (3+2) Annulation of Azaoxyallyl Cations" DiPoto, M. C.; Wu, J. Org. Lett. 2018, 499-501.

• "A Quinolinol-Based Small Molecule with Anti-MRSA Activity that Targets Bacterial Membrane and Promotes Fermentative Metabolism" Nair, D. R.; Chen, J.; Monteiro, J. M.; Josten, M.; Pinho, M.; Sahl, H.-G.; Wu, J.; Cheung, A. J. Antibiot. (Tokyo), 2017 July 12.

• "Transition Metal-Free C3 Arylation of Indoles with Aryl Halides" Chen, J.; Wu, J. Angew. Chem. Int. Ed. 2017, 56, 3951-3955.

• "Stereoselective Synthesis and Biological Evaluation of C1-Epimeric and Desmethyl Monomeric Nuphar Analogues" Li, H.; Cooke, T. J.; Korotkov, A.; Chapman, C. W.; Eastman, A.; Wu, J. J. Org. Chem. 2017, 82, 2648-2655.

• "Synthetic Small Molecule GLP-1 Secretagogues Prepared by Means of a Three-Component Indole Annulation Strategy" Chepurny, O. G.; Leech, C. A.; Tomanik, M.; DiPoto, M. C.; Li, H.; Han, X.; Meng, Q.; Cooney, R. N.; Wu, J.; Holz, G. G. Sci. Rep. 2016, 28934.

• "Enantioselective Formal Syntheses of 11 Nuphar Alkaloids and Discovery of Potent Apoptotic Monomeric Analogues" Li, H.; Korotkov, A.; Chapman, C. W.; Eastman, A.; Wu, J. Angew. Chem. Int. Ed. 2016, 55, 3509−3513.

• "Dearomative Indole (3+2) Reactions with Azaoxyallyl Cations − New Method for the Synthesis of Pyrroloindolines" DiPoto, M. C.; Hughes, R. P.; Wu, J. J. Am. Chem. Soc. 2015, 137, 14861-14864.

• "Vinylogous Mukaiyama−Michael Reactions of Dihydropyridinones" Li, H.; Wu, J. Org. Lett. 2015, 17, 5424−5427.

• "Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids" Korotkov, A.; Li, H.; Chapman, C. W.; Xue, H.; MacMillan, J. B.; Eastman, A.; Wu, J. Angew. Chem. Int. Ed. 2015, 54, 10604-10607.

• "Regioselective Formal Hydroamination of Styrenes with 1-Phenyl-1H-tetrazole-5-thiol" Savolainen, M. A.; Han, X.; Wu, J. Org. Lett. 2014, 16, 4349−4351.

• "Dearomative Indole (3+2) Cycloaddition Reactions" Li, H.; Hughes, R. P.; Wu, J. J. Am. Chem. Soc. 2014, 136, 6288−6296. 

• "Markovnikov-Selective Hydrothiolation of Styrenes: Application to the Synthesis of Stereodefined Trisubstituted Olefins" Savolainen, M. A.; Wu, J. Org. Lett. 2013, 15, 3802−3804.

• "Redox Chain Reaction - Indole and Pyrrole Alkylation with Unactivated Secondary Alcohols" Han, X.; Wu, J. Angew. Chem. Int. Ed. 2013, 52, 4637−4640.

• "Ga(III)-Catalyzed Three-Component (4+3) Cycloaddition Reactions" Han, X.; Li, H.; Hughes, R. P.; Wu, J. Angew. Chem. Int. Ed. 2012, 51, 10390−10393.

• "Palladium-Catalyzed Allylic Fluorination of Cinnamyl Phosphorothioate Esters" Lauer, A. M.; Wu, J. Org. Lett. 2012, 14, 5138−5141.

• "Phosphorothioic Acids as Surrogates for H2S - Synthesis of Chiral Tetrahydrothiophenes" Robertson, F. J.; Wu, J. J. Am. Chem. Soc. 2012, 134, 2775−2780.

• "Cu(I)-Catalyzed, alpha-Selective, Allylic Alkylation Reactions between Phosphorothioate Esters and Organomagnesium Reagents" Lauer, A. M.; Mahmud, F.; Wu, J. J. Am. Chem. Soc. 2011, 133, 9119−9112. (This report was highlighted in Synfacts 2011, 9, 1009.)

• "Direct Annulation and Alkylation of Indoles with 2-Aminobenzyl Alcohols Catalyzed by TFA" Robertson, F. J.; Kenimer, B. D.; Wu, J. Tetrahedron 2011, 67, 4327−4332. (Invited Contribution - Symposium in Print: Tetrahedron Young Investigators Award for Prof. Dean Toste)

• "Ga(OTf)3-Catalyzed Direct Substitution of Alcohols with Sulfur Nucleophiles" Han, X.; Wu, J. Org. Lett. 2010, 12, 5780−5782.

• "Convenient Synthesis of Allylic Thioethers from Phosphorothioate Esters and Alcohols" Robertson, F. J.; Wu, J. Org. Lett. 2010, 12, 2668−2671.

• "Mild Two-Step Process for the Transition-Metal-Free Synthesis of Carbon−Carbon Bonds from Allylic Alcohols/Ethers and Grignard Reagents" Han, X.; Zhang, Y.; Wu, J. J. Am. Chem. Soc. 2010, 132, 4104−4106. (This report was highlighted in Synfacts 2010, 6, 700.)

• "(3+2)-Cycloaddition Reactions of Oxyallyl Cations" Li, H.; Wu, J. Synthesis 2015, 47, 22−33.

• "Review of Recent Advances in Nucleophilic C-F Bond-forming Reactions" Wu, J. Tetrahedron Lett. 2014, 55, 4289–4294. 

• "Diethylphosphorothioic Acid" Wu, J. Encyclopedia of Reagents for Organic Synthesis, 2014, DOI: 10.1002/047084289X.rn01667