Professor of Chemistry
Research in the Wu group focuses on the development of new reactions for synthesizing compounds that have potential therapeutic value. These include (4+3) and (3+2) cycloadditions with indole, redox chain reactions, etc. In particular, we have identified molecules that can up-regulate the secretion of GLP-1 (glucagon-like peptide-1), inhibit the growth of MRSA, and induce apoptosis in leukemia cells. For each of these projects, we have teamed up with biological collaborators to study mechanisms of action and identify more potent analogues.
- A.B. Princeton University 1994-1998
- Ph.D. Harvard University 2001-2005
- NIH Postdoctoral Fellow Stanford University 2005-2007
- Associate Chemist Merck Process Research 1999-2001
"Regiodivergent (3 + 2) Annulation Reactions of Oxyallyl Cations" Protich, Z.; Lowder, L. L.; Wu, J. Chem. Sci. 2023, 14, 5196−5203.
"Diversification of Nucleophile-Intercepted Beckmann Fragmentation Products and Related Density Functional Theory Studies" Lowder, L. L.; Zhao, F.; Vaughan M. M.; Houk, K. N.; Liu, F.; Wu, J., J. Org. Chem. 2020, 85, 11396–11408.
"Nucleophile-intercepted Beckmann Fragmentation Reactions" Touchette, S. J.; Dunkley, E. M.; Lowder, L. L. Wu, J. Chem. Sci. 2019, 10, 7812−7815.
"Nuphar Alkaloids Induce Very Rapid Apoptosis Through a Novel Caspase-Dependent but BAX/BAK-Independent Pathway" Mallick, D. J.; Korotkov, A.; Li, H.; Wu, J.; Eastman, A. Cell Bio. Toxicol. 2019, 35, 435−443.