Kyle S. Smith

Associate Professor
Academic Appointments

Director of Graduate Studies

I conduct research on how the brain works to generate reward, motivation, actions, and habits. My work incorporates techniques to record neural activity, modulate neuronal activity at sub-second timescales, study brain chemistry, and map brain connections. The research is relevant to understanding disorders of reward and action, like addiction, Parkinson’s disease, and obsessive-compulsive spectrum disorders.

Center for Social Brain Sciences
Psychological and Brain Sciences
B.A., Indiana University
M.S., University of Michigan
Ph.D., University of Michigan
Post-doc, M.I.T.

Selected Publications

Graybiel AM, Smith KS (2014).  How the brain makes and breaks habits.  Scientific American, June issue (cover article).  Link to site.

Smith KS, Graybiel AM (2014). Investigating habits:  strategies, technologies, and models.  Frontiers in Behavioral Neuroscience, 8:39.  Link to article.

Smith KS, Graybiel AM (2013). A dual operator view of habitual behavior reflecting cortical and striatal dynamics. Neuron, 79(2):361-74.  (Link for video abstract)

Smith KS, Graybiel AM (2013). Using optogenetics to study habits. Brain Research, 1511:102-14.

Smith KS, Virkud A, Deisseroth K, Graybiel AM (2012). Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex. Proceedings of the National Academy of Sciences, 109(46):18932-7.

Smith KS, Berridge KC, Aldridge JW (2011). Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. Proceedings of the National Academy of Sciences, 108(27):E255-64.

Smith KS, Tindell AJ, Aldridge JW, Berridge KC (2009). Ventral pallidum roles in reward and motivation. Behavioural Brain Research, 96(2):155-67.

Smith KS, Mahler SV, Peciña S, Berridge KC (2009). Hedonic hotspots: brain generation of sensory pleasures. In: Berridge KS and Kringelbach ML (Eds.), Pleasures of the Brain. Oxford, England: Oxford University Press.

Smith KS, Berridge KC (2007). Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. The Journal of Neuroscience, 27(7):1594-1605.

Smith KS, Berridge KC (2005). The ventral pallidum and hedonic reward: neurochemical maps of‘liking’and food intake. The Journal of Neuroscience, 25(38):8637-49.

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