Lee Alan Witters

Academic Appointments

Eugene W. Leonard 1921 Professor of Medicine, Medical Education & Biochemistry, Geisel School of Medicine at Dartmouth
Professor of Biological Sciences, Dartmouth College

Trained as a physician, an endocrinologist, and biochemist, my passion is the education of those who might travel one or more of these roads in the future. The exploration of human biology begins with the experience of being human in all its dimensions, be they physiologic, social, or cultural. Guiding students through these dimensions as a small part of their ‘becoming’ is my personal reward.

HB 6044
Biological Sciences
A.B. Oberlin College
M.D. University of Rochester School of Medicine and Dentistry

Selected Publications

Hurley, RL, Barre, LK, Wood, SD, Anderson, KA, Kemp, BE, Means, AR and Witters, LA (2006), Regulation of AMP-activated protein kinase by multi-site phosphorylation in response to agents that elevate cellular cAMP, J. Biol. Chem. 281, 36662-36672,

Barre, L, Richardson, C, Hirshman, MF, Brozinick, Fiering, S, Kemp, BE, Goodyear, LJ and Witters, LA (2007) A genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation, Am J Physiol Endo Metab, 292, E802-811

Gleason, CE, Lu, D, Witters, LA, Newgard, CB and Birnbaum, MJ, (2007) The role of AMPK and mTOR in nutrient sensing in pancreatic β-cells, J. Biol. Chem., 282, 10341-103451

Roecki, KSC, Hirshman, MF, Brandauer, J, Fujii, N.. Witters, LA and Goodyear, LJ (2007), Skeletal Muscle Adaptation to Exercise Training AMP-Activated Protein Kinase Mediates Muscle Fiber Type Shift, Diabetes, 56, 2062-2069

Anderson, KA, Riber, T, Lin, F, Noeldner, P, Green, M, Murhlbauer, MJ, Witters LA, Kemp, BE and Means, AM (2008) A role for CaMKK2 in hypothalamic regulation of energy balance, Cell Metabolism, 7, 377-388

Folmes, KD, Witters LA, Allard, MF, Young ME and Dyck, JRB (2007) The AMPK gamma-1 R70Q mutant regulated multiple metabolic and growth pathways in the cardiac myocyte, Am J Physiol Heart Circ Physiol., 293(6):H3456-64

Vadasz, I, Dada, LA, Briva, A, C hen, J, Welch, LC, Diaz, I, Lecuona, E, Chandel, NS, Witters, LA, Seeger, W and Sznajder, JI (2008) AMP-activated protein kinase mediates the high CO2-induced alveolar epithelial dysfunction by down-regulating the Na,K-ATPase, J Clin Invest, 118(2):752-62

Ho, RC, Fujii, N, Witters, La, Hirshman, MF and Goodyear, LJ (2007) Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle, Biochem Biophys Res Comm, 362(2):354-9

Iseli, TJ, Oakhill, JS, Bailey, MF, Wee, S, Walter, M, van Denderen, BJ, Castelli, LA, Katsis, F, Witters, LA, Stapeton, D, Macauley, SL, Mickhell, BJ and Kemp, BE (2008) AMPK subunit interactions: β1 Thr-263 and Tyr-267 are required for β1:γ1 association, J Biol Chem, 283(8):4799-807

Witters, LA (2008) A Diligent Effort, Dartmouth Medicine, 32, 52-65

Witters, LA, Luciano, M, Williams, C and Yang, J (2008), Diabetes Detective, Dartmouth Medicine, 33, 36-41

Gusarova, GA, Dada, LA, Kelly, A, Brodie, C, Witters, LA and Sznajder, JI (2009) α-1-AMP-activated protein kinase (AMPK) regulates hypoxia-induced NaK-ATPase encocytosis via direct phosphorylation of PKCζ, Mol Cell Biol, 29, 3455-3464

Joly, E, Roduit, R, Peyot, M-L, Habinowski, SA, Ruderman, N, Witters, LA and Prentki, M (2009) Glucose represses peroxisome proliferator-activated receptor α gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell, J Diabetes, 1. 263-272

Baumrin, E, Corbett, W, Kulkarni, A and Witters LA (2009) The most unspeakable terror, Dartmouth Medicine, 34, 44-57

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