Mark R. Spaller

|Non-specific Courtesy Appt
Academic Appointments
  • Associate Professor, Medical Education

  • Adjunct Associate Professor, Biological Sciences

  • Adjunct Associate Professor, Chemistry


Dartmouth College
HB 6128




  • B.S. University of Texas at Austin
  • Ph.D. University of Texas at Austin

Selected Publications

  • Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA. "PTEN recruitment controls synaptic and cognitive function in Alzheimer's models." Nat Neurosci. 2016, 19, 443-53

    Marshall J, Wong KY, Rupasinghe CN, Tiwari R, Zhao X, Berberoglu ED, Sinkler C, Liu J, Lee I, Parang K, Spaller MR, Hüttemann M, Goebel DJ. "Inhibition of N-methyl-D-aspartate-induced retinal neuronal death by polyarginine peptides Is linked to the attenuation of stress-induced hyperpolarization of the inner mitochondrial membrane potential." Biol Chem. 2015, 290, 22030-48

    Pal K, Pletnev AA, Dutta SK, Wang E, Zhao R, Baral A, Yadav VK, Aggarwal S, Krishnaswamy S, Alkharfy KM, Chowdhury S, Spaller MR, Mukhopadhyay D. "Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth." Mol Cancer Ther. 2014, 13, 2264-75

    Amacher JF, Zhao R, Spaller MR, Madden DR. "Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain." PLoS One 2014, 19;9(8):e103650

    LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY. "A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia." Neuroscience. 2010, 167, 490-500

    Sharma SC, Memic A, Rupasinghe CN, Duc AC, Spaller MR. "T7 phage display as a method of peptide ligand discovery for PDZ domain proteins." Biopolymers. 2009, 92, 183-93