Mary Lou Guerinot

Academic Appointments

Professor of Biological Sciences
Ronald and Deborah Harris Professorship in the Sciences
Professor in the Molecular and Cellular Biology Graduate Program
Professor in the Microbiology and Molecular Pathogenesis Program
Fellow of the National Academy of Sciences
Fellow of the American Association for the Advancement of Science
Fellow of the American Society of Plant Biologists

I study the molecular mechanisms of metal ion uptake and its regulation in prokaryotic and eukaryotic cells using a combined genetic, molecular, and biochemical approach. My goal is to understand the functional connections between genes, proteins, metabolites, and mineral ions. I’m also looking at the reduction of iron by a family of membrane-bound Fe(III) reductases and metal metabolism in the symbiosis between Bradyrhizobium japonicum and soybeans.

HB 6044
Biological Sciences
B.S. Cornell University
Ph.D. Dalhousie University

Selected Publications

Riaz, N., Guerinot, M.L. (2021) All Together Now: Regulation of the Iron Deficiency Response. J Exp Bot. Jan 15:erab003. doi: 10.1093/jxb/erab003. Online ahead of print. PMID: 33449088 

Ruang-Areerate, P., Travis, A.J., Pinson, S.R.M., Tarpley, L., Eizenga, G.C., Guerinot, M.L., Salt, D.E., Douglas, A., Price, A.H., Norton, G.J. (2020) Genome-wide association mapping for grain manganese in rice (Oryza sativa L.) using a multi-experiment approach. Heredity (Edinb). Nov 24. doi: 10.1038/s41437-020-00390-w. PMID: 33235293 

Mu, S., Yamaji, N., Sasaki, A., Luo, L., Du, B., Che, J., Shi, H., Zhao, H., Huang, S., Deng, F., Shen, Z., Guerinot, M.L., Zheng, L., Ma, J.F. (2020) A transporter for delivering zinc to the developing tiller bud and panicle in rice.  Plant J. Nov 9. doi: 10.1111/tpj.15073. PMID: 33169459 

Fischer, S., Sánchez-Bermejo, E., Xu, X., Flis, P., Ramakrishna, P., Guerinot, M.L., Zhao, F.J., Salt, D.E. (2020) Targeted expression of the arsenate reductase HAC1 identifies cell-type specificity of arsenic metabolism and transport in plant roots. J Exp Bot. Oct 10;72(2):415-25. doi: 10.1093/jxb/eraa465.  PMID: 33038235

Kim, S.A., LaCroix, I.S., Gerber, S.A., Guerinot, M.L. (2019) The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.  Proc Natl Acad Sci U S A. Dec 10;116(50):24933-24942. doi: 10.1073/pnas.1916892116. . PMID: 31776249

Huang, X.Y., Liu, H., Zhu, Y.F., Pinson, S.R.M., Lin, H.X., Guerinot, M.L., Zhao, F.J., Salt, D.E. (2019) Natural variation in a molybdate transporter controls grain molybdenum concentration in rice. New Phytol. Oct 19. doi: 10.1111/nph.15546. PMID: 30339276

Nachman, K.E., Punshon, T., Rardin, L., Signes-Pastor, A.J., Murray, C.J., Jackson, B.P., Guerinot, M.L., Burke, T.A., Chen, C.Y., Ahsan, H., Argos, M., Cottingham, K.L., Cubadda, F., Ginsberg, G.L., Goodale, B.C., Kurzius-Spencer, M., Meharg, A.A., Miller M.D., Nigra, A.E., Pendergrast, C.B., Raab, A., Reimer, K., Scheckel, K.G., Schwerdtle, T., Taylor, V.F., Tokar, E.J., Warczak, T.M. and Karagas, M.R. (2018) Opportunities and Challenges for Dietary Arsenic Intervention. Environ Health Perspect. Aug;126(8):84503. doi: 10.1289/EHP3997. PMID: 30235424

Ricachenevsky, F.K., Punshon, T., Lee, S., Oliveira, B.H.N., Trenz, T.S., Maraschin, F.D.S., Hindt, M.N., Danku, J., Salt, D.E., Fett, J.P. and Guerinot, M.L. (2018) Elemental Profiling of Rice FOX Lines Leads to Characterization of a New Zn Plasma Membrane Transporter, OsZIP7. Front Plant Sci. Jul 3;9:865. doi: 10.3389/fpls.2018.00865. eCollection 2018. PMID: 30018622

Chu, H.H., Car, S., Socha, A.L., Hindt, M.N., Punshon, T. and Guerinot, M.L. (2017) The Arabidopsis MTP8 transporter determines the localization of manganese and iron in seeds. Sci Rep. Sep 8;7(1):11024. doi: 10.1038/s41598-017-11250-9. PMID: 28887568

Hindt, M.N., Akmakjian, G.Z., Pivarski, K.L., Punshon, T., Baxter, I., Salt, D.E. and Guerinot, M.L. (2017) BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana. Metallomics. 2017 Jul 19;9(7):876-890. doi: 10.1039/c7mt00152e. PMID: 28620661

Punshon, T., Jackson, B.P., Meharg, A.A., Warczak, T., Scheckel, K. and Guerinot, M.L. (2017) Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants. Sci. Total Environ.  Mar 1;581-582:209-220. doi: 10.1016/j.scitotenv.2016.12.111. Epub 2016 Dec 30. Review. PMID: 28043702

Huang, X.Y., Deng, F., Yamaji, N., Pinson, S.R., Fujii-Kashino, M., Danku, J., Douglas, A., Guerinot, M.L., Salt, D.E., Ma, J.F. (2016) A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain. Nat. Commun. 2016 Jul 8;7:12138. doi: 10.1038/ncomms12138. PMID:27387148

Mary, V., Schnell Ramos, M., Gillet, C., Socha, A.L., Giraudat, J., Agorio, A., Merlot, S., Clairet, C., Kim, S.A., Punshon, T,., Guerinot, M.L., Thomine, S.  (2015) Bypassing Iron Storage in Endodermal Vacuoles Rescues the Iron Mobilization Defect in the natural resistance associated-macrophage protein3natural resistance associated-macrophage protein4 Double Mutant. Plant Physiol. 2015 Sep;169(1):748-59. doi: 10.1104/pp.15.00380. Epub Jul 31. PMID: 26232490

Stanton, B.A., Caldwell, K., Congdon, C.B., Disney, J., Donahue, M., Ferguson, E., Flemings, E., Golden, M., Guerinot, M.L., Highman, J., James, K., Kim, C., Lantz, R.C., Marvinney, R.G., Mayer, G., Miller, D., Navas-Acien, A., Nordstrom, D.K., Postema, S., Rardin, L., Rosen, B., SenGupta, A., Shaw, J., Stanton, E., Susca, P. (2015) MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic. Curr Environ. Health Rep. Sep;2(3):329-37. doi: 10.1007/s40572-015-0057-9. PMID: 26231509

Zhai, Z., Gayomba, S.R., Jung, H.I., Vimalakumari, N.K., Piñeros, M., Craft, E., Rutzke, M.A., Danku, J., Lahner, B., Punshon, T., Guerinot, M.L., Salt, D.E., Kochian, L.V., Vatamaniuk, O.K. (2014) OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis. Plant Cell. May 27;26(5):2249-2264. PMID: 24867923

Socha, A. and M.L. Guerinot. (2014)  Mn-euvering manganese: the role of transporter gene family members in manganese uptake and mobilization in plants.  Front. Plant Sci. 5:106. doi: 10.3389/fpls.2014.00106

Norton, G.J., Douglas, A., Lahner, B., Yakubova, E., Guerinot, M.L., Pinson, S.R., Tarpley, L., Eizenga, G.C., McGrath, S.P., Zhao, F.J., Islam, M.R., Islam, S., Duan, G., Zhu, Y., Salt, D.E., Meharg, A.A., Price, A.H. (2014) Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites. PLoS One. Feb 25;9(2):e89685. doi: 10.1371/journal.pone.0089685. eCollection. PMID: 24586963

Hong, S., S.A. Kim, M.L. Guerinot and C.R. McClung.  2013.  Reciprocal interaction of the circadian clock with the Fe homeostasis network in Arabidopsis thaliana.  Plant Physiol. 163: 893-903. PMCID: PMC3561027

Schroeder, J.I., E. Delhaize, W.B. Frommer, M.L. Guerinot, M.J. Harrison, L. Herrera-Estrella, T. Horie, L.V. Kochian, R. Munns, N.K. Nishizawa, Y.-F. Tsay and D. Sanders.  2013.  Using membrane transporters to improve crops for sustainable food production.  Nature 497: 60-66.

Hosmani, P.S., T. Kamiya, J. Danku S. Naseer, N. Geldner, M.L. Guerinot and D.E. Salt.  2013.   A dirigent-domain containing protein is part of the machinery required for formation of the lignin-based Casparian strip in the root.  Proc. Natl. Acad. Sci. U.S.A.  110:14498-503

Zhang, M, S.R.M. Pinson, L. Tarpley, X. Huang, B. Lahner, E. Yakubova, M.L. Guerinot, and D.E. Salt.  2013.  Mapping and validation of quantitative trait loci associated with concentrations of 16 elements in unmilled rice grain.  Theor. Appl. Genet.  10.1007/s00122-013-2207-5

Palmer, C., M.N. Hindt, H. Schmidt, S. Clemens and M.L. Guerinot.  2013.  MYB10 and MYB72 Are required for growth under iron-limiting conditions.  PLoS Genet.  9(11):e1003953

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