Patrick Dolph

Academic Appointments

Associate Professor of Biological Sciences
Molecular & Cellular Biology Graduate Program

351 Life Sciences Center
HB 6044
Biological Sciences
B.S. Oregon State University
M.S. Ohio State University
Ph.D. New York University Medical Center

Selected Publications

Roles of the Drosophila SK channel (dSK) in courtship memory. Abou Tayoun AN, Pikielny C, Dolph PJ. PLoS One. 2012;7(4):e34665. doi: 10.1371/journal.pone.0034665. Epub 2012 Apr 11. PMID: 22509342 [PubMed - indexed for MEDLINE]

Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila. Kinser RD, Dolph PJ. Neurobiol Dis. 2012 Jun;46(3):655-62. doi: 10.1016/j.nbd.2012.03.004. Epub 2012 Mar 9. PMID: 22426392[Pu bMed - indexed for MEDLINE]

Gavin, B A, M J Dolph, N R Deleault, J C Geoghegan, V Khurana, M B Feany, P J Dolph, and S Supattapone, “Accelerated Accumulation of Misfolded Prion Protein and Spongiform Degeneration in a Drosophila Model of Gerstmann-Sträussler-Scheinker Syndrome,” The Journal of Neuroscience , 26:48 (November 2006) 12408-12414.

Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish. Chinchore Y, Gerber GF, Dolph PJ. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E605-12. doi: 10.1073/pnas.1110666109. Epub 2012 Feb 10. PMID: 22328149 [PubMed - indexed for MEDLINE]

Characterization of two dominant alleles of the major rhodopsin-encoding gene ninaE in Drosophila. Mitra A, Chinchore Y, Kinser R, Dolph PJ. Mol Vis. 2011;17:3224-33. Epub 2011 Dec 14. PMID: 22194648 [PubMed - indexed for MEDLINE]

The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network. Abou Tayoun AN, Li X, Chu B, Hardie RC, Juusola M, Dolph PJ. J Neurosci. 2011 Sep 28;31(39):13897-910. doi: 10.1523/JNEUROSCI.3134-11.2011. PMID: 21957252 [PubMed - indexed for MEDLINE]

Cell-autonomous requirement for DNaseII in nonapoptotic cell death. Bass BP, Tanner EA, Mateos San Martín D, Blute T, Kinser RD, Dolph PJ, McCall K. Cell Death Differ. 2009 Oct;16(10):1362-71. doi: 10.1038/cdd.2009.79. Epub 2009 Jun 26. PMID: 19557011 [PubMed - indexed for MEDLINE]

Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration. Chinchore Y, Mitra A, Dolph PJ. PLoS Genet. 2009 Feb;5(2):e1000377. doi: 10.1371/journal.pgen.1000377. Epub 2009 Feb 13. PMID: 19214218 [PubMed - indexed for MEDLINE]


The role of carcinine in signaling at the Drosophila photoreceptor synapse. Gavin BA, Arruda SE, Dolph PJ. PLoS Genet. 2007 Dec;3(12):e206. PMID: 18069895 [PubMed - indexed for MEDLINE]


Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S. J Neurosci. 2006 Nov 29;26(48):12408-14. PMID: 17135402 [PubMed - indexed for MEDLINE]

An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor. Orem NR, Xia L, Dolph PJ. J Cell Sci. 2006 Aug 1;119(Pt 15):3141-8. Epub 2006 Jul 11. PMID: 16835270 [PubMed - indexed for MEDLINE]

Molecular cloning of the pawn locus from Drosophila melanogaster. Arruda SE, Dolph PJ. Gene. 2003 May 22;310:169-73. PMID: 12801644 [PubMed - indexed for MEDLINE]


Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons. Deleault NR, Dolph PJ, Feany MB, Cook ME, Nishina K, Harris DA, Supattapone S. J Neurochem. 2003 Jun;85(6):1614-23. PMID: 12787080

Epitope masking of rhabdomeric rhodopsin during endocytosis-induced retinal degeneration. Orem NR, Dolph PJ. Mol Vis. 2002 Dec 2;8:455-61. PMID: 12486400

Arrestin: roles in the life and death of retinal neurons. Dolph PJ. Neuroscientist. 2002 Aug;8(4):347-55. Review. PMID: 12194503

Orem, N R, and P J Dolph, “Loss of the Phospholipase C Gene Product Induces Massive Endocytosis of Rhodopsin and Arrestin in Drosophila Photoreceptors,” Vision Research , 42:4 (February 2002) 497-505.

The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration. Alloway PG, Howard L, Dolph PJ. Neuron. 2000 Oct;28(1):129-38. PMID: 11086989

A role for the light-dependent phosphorylation of visual arrestin. Alloway PG, Dolph PJ. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6072-7. PMID: 10339543

An eye-specific G beta subunit essential for termination of the phototransduction cascade. Dolph PJ, Man-Son-Hing H, Yarfitz S, Colley NJ, Deer JR, Spencer M, Hurley JB, Zuker CS. Nature. 1994 Jul 7;370(6484):59-61. PMID: 8015606

Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo. Dolph PJ, Ranganathan R, Colley NJ, Hardy RW, Socolich M, Zuker CS. Science. 1993 Jun 25;260(5116):1910-6. PMID: 8316831

olation of a novel visual-system-specific arrestin: an in vivo substrate for light-dependent phosphorylation. LeVine H 3rd, Smith DP, Whitney M, Malicki DM, Dolph PJ, Smith GF, Burkhart W, Zuker CS. Mech Dev. 1990 Dec;33(1):19-25. PMID: 2129011

Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex. Dolph PJ, Huang JT, Schneider RJ. J Virol. 1990 Jun;64(6):2669-77. Erratum in: J Virol 1990 Aug;64(8):4042. PMID: 1692346


Secondary structure analysis of adenovirus tripartite leader. Zhang Y, Dolph PJ, Schneider RJ. J Biol Chem. 1989 Jun 25;264(18):10679-84. PMID: 2732243

The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation. Dolph PJ, Racaniello V, Villamarin A, Palladino F, Schneider RJ. J Virol. 1988 Jun;62(6):2059-66. PMID: 2835510

Characterization of a gene cluster for exopolysaccharide biosynthesis and virulence in Erwinia stewartii. Dolph PJ, Majerczak DR, Coplin DL. J Bacteriol. 1988 Feb;170(2):865-71. PMID: 2828330

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