Sharon E. Bickel
Professor of Biological Sciences
Molecular and Cellular Biology Graduate Program
Chromosome segregation errors in human oocytes are the leading cause of miscarriages and birth defects and their frequency increases dramatically as women age. Work in my laboratory is focused on defining the pathway of events necessary for chromosomes to ""do the right thing"" during meiosis and understanding the molecular events that cause reduced fidelity of meiotic chromosome segregation as oocytes age.
- B.A. Austin College
- Ph.D. Baylor College of Medicine
Perkins, A.T. and Bickel, S.E.. (2017) Using Fluorescence In Situ Hybridization (FISH) to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes .J Vis Exp. Dec 6;(130). doi:10.3791/56802. PMID:29286418 Link to Video
Perkins, A.T., Das, T.M., Panzera, L.C. and Bickel, S.E. (2016) Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors. PNAS: doi: 10.1073/pnas.1612047113.
Giauque, C.C. and Bickel, SE. (2016) Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes. Genetics.: May;203(1):173-89. doi: 10.1534/genetics.115.186460.
Weng, K.A., Jeffreys, C.A. and Bickel, S.E. (2014). Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation. PLoS Genet.: Sep 11;10(9):