Professor of Biological Sciences
Professor in the Molecular and Cellular Biology Graduate Program
I am interested in understanding how eukaryotic cells organize, position, and segregate their organelles during asymmetric cell divisions. We combine classical genetics and live-cell microscopy with biochemical and biophysical techniques to elucidate the molecular pathways that regulate the microtubule cytoskeleton and the motor proteins responsible for organellar interaction and positioning in our model system budding yeast.
- B.S., University of Iowa
- Ph.D., Johns Hopkins University
Omer, S., Brock, K., Beckford, J., Lee, W.-L. (2020) Overexpression of Mdm36 reveals Num1 foci that mediate dynein-dependent microtubule sliding in budding yeast. Journal of Cell Science. Oct 15;133(20)
Zhu Y, Tan W., W.-L. Lee (2018). An in vitro Microscopy-based Assay for Microtubule-binding and Microtubule-crosslinking by Budding Yeast Microtubule-associated Protein. Bio-protocol 8(23): e3110. doi: 10.21769/BioProtoc.3110.
Greenberg S.R., Tan W., W.-L. Lee (2018). Num1 versus NuMA: insights from two functionally homologous proteins. Biophysical Reviews, 10(6):1631-1636. doi: 10.1007/s12551-018-0472-x.
Omer S., Greenberg S.R., W.-L. Lee (2018). Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1. Elife, 7:e36745. doi: 10.7554/eLife.36745.