Yasmine Kamen
Postdoctoral Scholar
National MS Society Postdoctoral Fellow
I study interactions between oligodendrocyte lineage cells and neurons. During my doctoral studies, I used electrophysiology to examine how neurotransmitter signaling to oligodendrocyte precursor cells modulates their capacity to proliferate and differentiate into myelinating oligodendrocytes. As a postdoctoral fellow in the Hill lab, I use intravital imaging with genetic labels and cellular physiology sensors to study how myelinating oligodendrocytes modulate neuronal function, with a focus on understanding these processes during healthy brain plasticity and in neurological disorders like Multiple Sclerosis.
Contact
Department(s)
Biological Sciences
Education
- B.Sc. McGill University
- Ph.D. University of Cambridge
Selected Publications
Kamen Y, Chapman TW, Piedra EP, Ciolkowski ME, Hill RA. Transient upregulation of procaspase-3 during oligodendrocyte fate decisions. The Journal of Neuroscience (2025). doi: 10.1523/JNEUROSCI.2066-24.2025.
Chapman TW, Kamen Y, Piedra ET, and Hill RA. Oligodendrocyte maturation alters the cell death mechanisms that cause demyelination. The Journal of Neuroscience (2024) doi: 10.1523/JNEUROSCI.1794-23.2024 PMID: 38395617
Kamen Y#, Evans KA, Sitnikov S, Spitzer SO, de Faria O Jr, Yucel M, Káradóttir RT#. Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells. Scientific Reports (2024) doi: 10.1038/s41598-024-53615-x. PMID: 38374232 #co-corresponding author
Pivoňková H*, Sitnikov S*, Kamen Y*, Vanhaesebrouck A, Matthey M, Spitzer SO, Ng YT, Tao C, de Faria O Jr, Varga BV, Káradóttir RT. Heterogeneity in oligodendrocyte precursor cell proliferation is dynamic and driven by passive bioelectrical properties. Cell Reports (2024) doi: 10.1016/j.celrep.2024.114873 PMID: 39423130 *co-first author